Fig. 1. Expression of SUR2 in VSMCs and effects of diazoxide on SU-induced VSMCs proliferation. The expression of SUR2 in VSMCs was tested by immunofluorescence assay (× 200). Compared with negative control (A), SUR2 was widely expressed in VSMCs (B). The proliferation of VSMCs in each group was evaluated by CCK-8 assay in the absence (C) or presence (D) of diazoxide, a K_ATP channel opener. Data are expressed as the mean ± SEM of triplicate determinations. * P<0.05 versus control.